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Towards high-throughput flim for protein-protein interaction screening of live cells and tissue microarrays

Abstract:

Studying cellular protein-protein interactions in situ requires a technique such as fluorescence resonance energy transfer (FRET) which is sensitive on the nanometer scale. Observing FRET is significantly simplified if the fluorescence lifetime of the donor can be monitored. Results from live cells and tissue micro arrays are presented from an automated microscope incorporating time-domain TCSPC fluorescence lifetime imaging (FLIM). Novel hardware and software with a modular approach and scri...

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Publication status:
Published

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Publisher copy:
10.1109/ISBI.2008.4541006

Authors


Barber, PR More by this author
Pierce, GP More by this author
Ameer-Beg, SM More by this author
Matthews, DR More by this author
Carlin, LM More by this author
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Pages:
356-359
Publication date:
2008
DOI:
ISSN:
1945-7928
URN:
uuid:d067185a-d95c-4470-9a3d-291b9a957e2d
Source identifiers:
73001
Local pid:
pubs:73001
ISBN:
978-1-4244-2002-5

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