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Understanding hypoxia signalling in cells--a new therapeutic opportunity?

Abstract:

The possibility that cells possess specific interfaces with molecular oxygen that have a prime function in biological control has long interested biologists. Specific 'oxygen-sensing' mechanisms have been defined in bacteria and yeast, but, until recently, have remained elusive in higher organisms. Studies of hypoxia pathways have now, however, revealed the existence of a series of non-haem Fe(ll) and 2-oxoglutarate-dependent dioxygenases that catalyse oxygen-regulated hydroxylation of specif...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
Clinical medicine (London, England)
Volume:
6
Issue:
6
Pages:
573-578
Publication date:
2006
DOI:
EISSN:
1473-4893
ISSN:
1470-2118
URN:
uuid:d053281b-d722-46b3-a431-871fae623fa4
Source identifiers:
25271
Local pid:
pubs:25271

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