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A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

Abstract:

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl. While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S-adenosyl meth...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1126/sciadv.aat2720

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Biology
Role:
Author
ORCID:
0000-0002-7568-0544
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Role:
Author
ORCID:
0000-0003-3516-3507
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Wellcome Trust More from this funder
ETH Zürich More from this funder
University of Minnesota More from this funder
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
4
Issue:
8
Pages:
Article: eaat2720
Publication date:
2018-08-24
Acceptance date:
2018-07-17
DOI:
ISSN:
2375-2548
Pubs id:
pubs:911604
URN:
uri:d051ec44-9afa-4b22-933b-2888d309eb80
UUID:
uuid:d051ec44-9afa-4b22-933b-2888d309eb80
Local pid:
pubs:911604
Language:
English

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