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Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Abstract:

The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with diseas...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2013.08.034

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Journal:
Cell More from this journal
Volume:
155
Issue:
1
Pages:
57-69
Publication date:
2013-09-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674

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