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Thesis

Investigation of the signalling and function of NOD2

Abstract:

NOD2 is an intracellular innate immune receptor expressed in dendritic cells and gastrointestinal epithelial cells. Polymorphisms in the NOD2 gene convey a strong predisposition to Crohn’s disease (CD), a form of inflammatory bowel disease. Understanding the function of NOD2, and in what way it is aberrant in the presence of NOD2 polymorphisms, would confer a valuable paradigm for understanding Crohn’s pathogenesis.

CD is thought to arise both from defects in the gut mucosal barrier...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Jesus College
Role:
Author

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Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:d04c56dd-1325-4ff3-8810-4991d2fd61b0
Local pid:
ora:7455
Deposit date:
2013-10-15

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