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Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9.

Abstract:

Matrix metalloproteinase-9 (MMP-9) produced by colorectal cancer cells is a critical determinant of metastatic disease progression and an attractive target for antimetastatic strategies to reduce colon cancer mortality. Cellular signaling by cyclic GMP (cGMP) regulates MMP-9 dynamics in various cell systems, and the bacterial enterotoxin receptor guanylyl cyclase C (GCC), the principle source of cGMP in colonocytes, which is overexpressed in colorectal cancers, inhibits tumor initiation and p...

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Publication status:
Published

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Authors


Pelta-Heller, J More by this author
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Journal:
Cancer research
Volume:
69
Issue:
8
Pages:
3529-3536
Publication date:
2009-04-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:d044dd02-13e0-45be-a3ac-0686591f1856
Source identifiers:
131309
Local pid:
pubs:131309

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