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Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

Abstract:

The final step in the biosynthesis of the plant signaling molecule ethylene is catalyzed by 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). ACCO requires bicarbonate as an activator and catalyzes the oxidation of ACC to give ethylene, CO2, and HCN. We report crystal structures of ACCO in apo-form (2.1 A resolution) and complexed with Fe(II) (2.55 A) or Co(II) (2.4 A). The active site contains a single Fe(II) ligated by three residues (His177, Asp179, and His234), and it is relatively op...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemistry and biology
Volume:
11
Issue:
10
Pages:
1383-1394
Publication date:
2004-10-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Source identifiers:
32880
Language:
English
Keywords:
Pubs id:
pubs:32880
UUID:
uuid:d03be2af-9307-47a6-990c-085a7f50267e
Local pid:
pubs:32880
Deposit date:
2012-12-19

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