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Can we teach an old drug new tricks?

Abstract:

Although resistance to chloroquine (CQ) has relegated it from modern chemotherapeutic strategies to treat . Plasmodium falciparum malaria, new evidence suggests that higher doses of the drug may exert a different killing mechanism and offers this drug a new lease of life. Whereas the established antimalarial mechanisms of CQ are usually associated with nanomolar levels of the drug, micromolar levels of CQ trigger a distinct cell death pathway involving the permeabilization of the digestive va...

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Publisher copy:
10.1016/j.pt.2012.02.005
Journal:
Trends in Parasitology More from this journal
Volume:
28
Issue:
6
Pages:
220-224
Publication date:
2012-06-01
DOI:
EISSN:
1471-5007
ISSN:
1471-4922
Language:
English
Keywords:
Pubs id:
pubs:335118
UUID:
uuid:d0371767-0bbd-4385-822d-d3d19a011311
Local pid:
pubs:335118
Source identifiers:
335118
Deposit date:
2013-11-17

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