Journal article icon

Journal article

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.

Abstract:

BACKGROUND: Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. METHODS: This meta-analysis included individual participant data from 22 trials of statin versus control (n=134,537; mean LDL cholesterol difference 1·08 mmol/L; median follow-up 4·8 years) and five trials of more versus less statin (n=39,612; difference 0·51 mmol/L; 5·1 years). Major vascular events were major coronary events (ie, non-fatal ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Population Health
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Blackwell, L More by this author
Expand authors...
Journal:
Lancet (London, England)
Volume:
380
Issue:
9841
Pages:
581-590
Publication date:
2012-08-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:d03391a1-ee81-4b78-aaf9-b30250a221c7
Source identifiers:
339767
Local pid:
pubs:339767

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP