The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.

Journal article

BACKGROUND: Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. METHODS: This meta-analysis included individual participant data from 22 trials of statin versus control (n=134,537; mean LDL cholesterol difference 1·08 mmol/L; median follow-up 4·8 years) and five trials of more versus less statin (n=39,612; difference 0·51 mmol/L; 5·1 years). Major vascular events were major coronary events (ie, non-fatal ...

Expand abstract

Authors: Mihaylova, B; Emberson, J; Blackwell, L; Keech, A; Simes, J

• Publication status: Published
• Journal: Lancet (London, England)
• Volume: 380
• Issue: 9841
• Pages: 581-590
• Publication date: 2012-08-01
• DOI: 10.1016/S0140-6736(12)60367-5
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Risk Assessment; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Cholesterol Treatment Trialists' (CTT) Collaborators; Treatment Outcome; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Cholesterol, LDL; Vascular Diseases