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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Abstract:

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ĝ‰Currency sign 1 × 10 -5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci repli...

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Publisher copy:
10.1038/ng.803

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Journal:
Nature Genetics
Volume:
43
Issue:
5
Pages:
429-436
Publication date:
2011-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d02cf5bf-ffea-45c9-838d-2eff8b42ed7d
Source identifiers:
149795
Local pid:
pubs:149795
Language:
English

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