Journal article
DNA-templated protein arrays for single-molecule imaging.
- Abstract:
-
Single-particle electron cryomicroscopy permits structural characterization of noncrystalline protein samples, but throughput is limited by problems associated with sample preparation and image processing. Three-dimensional density maps are reconstructed from high resolution but noisy images of individual molecules. We show that self-assembled DNA nanoaffinity templates can create dense, nonoverlapping arrays of protein molecules, greatly facilitating data collection. We demonstrate this tech...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/nl1037769
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Authors
Bibliographic Details
- Journal:
- Nano letters
- Volume:
- 11
- Issue:
- 2
- Pages:
- 657-660
- Publication date:
- 2011-02-01
- DOI:
- EISSN:
-
1530-6992
- ISSN:
-
1530-6984
- Source identifiers:
-
112503
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:112503
- UUID:
-
uuid:d019b834-a8ad-45d5-a842-6d8fc0f04d0d
- Local pid:
- pubs:112503
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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