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Structural determinants of conformationally selective, prion-binding aptamers.

Abstract:

We have recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind selectively to disease-associated beta-sheet-rich forms of the prion protein, PrP, from a number of mammalian species. These aptamers inhibit the accumulation of protease-resistant forms of PrP in a prion-seeded, in vitro conversion assay. Here we identify the minimal portions of two of these aptamers that retain binding specificity. We determine their secondary structures by a combination of mo...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m310928200

Authors


Bullock, M More by this author
Tahiri-Alaoui, A More by this author
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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
13
Pages:
13102-13109
Publication date:
2004-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:d0183eb0-cd50-4263-923c-67d6d02d933c
Source identifiers:
29455
Local pid:
pubs:29455

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