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Classical pathway complement destruction is not responsible for the loss of human erythrocytes during porcine liver perfusion.

Abstract:

BACKGROUND: Porcine livers perfused with human blood destroy 85% of human erythrocytes (red blood cells [RBC]) during prolonged extracorporeal perfusion, raising the possibility of a complement-mediated graft-versus-host effect. METHODS: Isolated porcine livers were perfused with fresh human blood. Plasma samples were analyzed for complement production by reverse CH50 analysis and porcine immunoglobulin class and specificity by enzyme-linked immunosorbent assay (ELISA) and flow cytometry. An...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
77
Issue:
9
Pages:
1416-1423
Publication date:
2004-05-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
147931
Language:
English
Keywords:
Pubs id:
pubs:147931
UUID:
uuid:d017b461-dc1d-45ef-aa17-bed2ff4888b2
Local pid:
pubs:147931
Deposit date:
2012-12-19

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