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Interleukin-33, friend and foe in type-2 immune responses

Abstract:

IL-33 is the most recent addition to the IL-1 cytokine family, identified in 2005 as the ligand of T1/ST2 and inducer of type-2 immune responses. IL-33 has been implicated in a wide range of disease settings, in anti-inflammatory responses and homeostasis, and thus signalling must be strictly regulated. Altered gene expression, post-translational modification, decoy receptor, and receptor signalling are all modulatory mechanisms used to control the IL-33 pathway. Understanding both the geneti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.coi.2016.05.004

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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
More by this author
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Medical Research Council More from this funder
Barrie Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Immunology Journal website
Volume:
42
Pages:
16-24
Publication date:
2016-05-24
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
Pubs id:
pubs:625633
URN:
uri:d017ae32-683b-4415-9812-29507e91ef20
UUID:
uuid:d017ae32-683b-4415-9812-29507e91ef20
Local pid:
pubs:625633
Language:
English
Keywords:

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