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Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity

Abstract:

Foot-and-mouth disease virus (FMDV) is a significant economically and distributed globally pathogen of Artiodactyla. Current vaccines are chemically inactivated whole virus particles that require large-scale virus growth in strict bio-containment with the associated risks of accidental release or incomplete inactivation. Non-infectious empty capsids are structural mimics of authentic particles with no associated risk and constitute an alternate vaccine candidate. Capsids self-assemble from th...

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Journal:
Journal of Virological Methods More from this journal
Volume:
187
Issue:
2
Pages:
406-412
Publication date:
2013-02-01
DOI:
EISSN:
1879-0984
ISSN:
0166-0934
Pubs id:
pubs:379436
UUID:
uuid:d016b381-16c1-4f45-97b1-8fa836766681
Local pid:
pubs:379436
Source identifiers:
379436
Deposit date:
2013-11-17

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