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MIG and the regulatory cytokines IL-10 and TGF-[beta]1 correlate with malaria vaccine immunogenicity and efficacy.

Abstract:

Malaria remains one of the world's greatest killers and a vaccine is urgently required. There are no established correlates of protection against malaria either for natural immunity to the disease or for immunity conferred by candidate malaria vaccines. The RTS,S/AS02A vaccine offers significant partial efficacy against malaria.mRNA expression of five key cytokines interferon-gamma (IFN-[gamma]), monokine induced by gamma (MIG), interleukin-10 (IL-10), transforming growth factor-[beta] (TGF-[...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0012557

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Funding agency for:
Dunachie, S
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Funding agency for:
Hill, A
Wellcome Trust More from this funder
PATH Malaria Vaccine Initiative More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
9
Article number:
e12557
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
95346

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