MIG and the regulatory cytokines IL-10 and TGF-[beta]1 correlate with malaria vaccine immunogenicity and efficacy.
Malaria remains one of the world's greatest killers and a vaccine is urgently required. There are no established correlates of protection against malaria either for natural immunity to the disease or for immunity conferred by candidate malaria vaccines. The RTS,S/AS02A vaccine offers significant partial efficacy against malaria.mRNA expression of five key cytokines interferon-gamma (IFN-[gamma]), monokine induced by gamma (MIG), interleukin-10 (IL-10), transforming growth factor-[beta] (TGF-[...Expand abstract
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