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Thesis

Studies on deacetoxy/deacetylcephalosporin C synthase

Abstract:

This thesis describes an investigation of the mechanism of the bifunctional, a-ketoglutarate dependent dioxygenase, deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS), which catalyses the ring-expansion of penicillin N to deacetoxycephalosporin C (DAOC) and the hydroxylation of this to deacetylcephalosporin C (DAC).

The conversion of the unnatural substrate 3-exomethylene cephalosporin C by DAOC/DACS has been investigated in detail. A new metabolite was isolated from incubation...

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Institution:
University of Oxford
Division:
MPLS
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1993
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
603840972
Language:
English
Subjects:
UUID:
uuid:d00c6130-a9ec-44f8-a1f5-0465dbaeb4f9
Local pid:
td:603840972
Deposit date:
2013-01-21

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