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The role of TASK-like K+ channels in oxygen sensing in the carotid body.

Abstract:

The carotid body plays an important role in initiating protective responses to hypoxemia. The primary oxygen sensing cells are the glomus or type 1 cells. Hypoxia evokes the secretion of neurotransmitters from these cells which then excite afferent nerves. This response is mediated via membrane depolarization and voltage-gated Ca2+ entry. Studies from this laboratory have revealed that membrane depolarization in response to hypoxia is primarily the result of inhibition of background K+ channe...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Williams, BA More by this author
Orozco, RV More by this author
Journal:
Novartis Foundation symposium
Volume:
272
Pages:
73-140
Publication date:
2006
EISSN:
1935-4657
ISSN:
1528-2511
URN:
uuid:d00bf588-0fdb-4f4a-8c42-d455c45c1398
Source identifiers:
312265
Local pid:
pubs:312265

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