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Journal article

The role of TASK-like K+ channels in oxygen sensing in the carotid body.

Abstract:

The carotid body plays an important role in initiating protective responses to hypoxemia. The primary oxygen sensing cells are the glomus or type 1 cells. Hypoxia evokes the secretion of neurotransmitters from these cells which then excite afferent nerves. This response is mediated via membrane depolarization and voltage-gated Ca2+ entry. Studies from this laboratory have revealed that membrane depolarization in response to hypoxia is primarily the result of inhibition of background K+ channe...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Novartis Foundation symposium
Volume:
272
Pages:
73-140
Publication date:
2006-01-01
EISSN:
1935-4657
ISSN:
1528-2511
Source identifiers:
312265
Language:
English
Keywords:
Pubs id:
pubs:312265
UUID:
uuid:d00bf588-0fdb-4f4a-8c42-d455c45c1398
Local pid:
pubs:312265
Deposit date:
2013-11-17

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