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Journal article

Regulation of receptor tyrosine kinase ligand processing.

Abstract:

A primary mode of regulating receptor tyrosine kinase (RTK) signaling is to control access of ligand to its receptor. Many RTK ligands are synthesized as transmembrane proteins. Frequently, the active ligand must be released from the membrane by proteolysis before signaling can occur. Here, we discuss RTK ligand shedding and describe the proteases that catalyze it in flies and mammals. We focus principally on the control of EGF receptor ligand shedding, but also refer to ligands of other RTKs...

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Publication status:
Published

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Publisher copy:
10.1101/cshperspect.a008995

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cold Spring Harbor perspectives in biology More from this journal
Volume:
6
Issue:
1
Pages:
a008995-a008995
Publication date:
2014-01-01
DOI:
EISSN:
1943-0264
ISSN:
1943-0264
Language:
English
Keywords:
Pubs id:
pubs:445946
UUID:
uuid:d00ac0c2-cda4-4fbe-aebb-f7c5909e5ffe
Local pid:
pubs:445946
Source identifiers:
445946
Deposit date:
2014-02-08

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