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Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes.

Abstract:

Many studies show that calcium reduces iron absorption from single meals, but the underlying mechanism is not known. We tested the hypothesis that calcium alters the expression and/or functionality of iron transport proteins. Differentiated Caco-2 cells were treated with ferric ammonium citrate and calcium chloride, and ferritin, DMT-1, and ferroportin were quantified in whole-cell lysate and cell-membrane fractions. Calcium attenuated the iron-induced increase in cell ferritin levels in a do...

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Publisher copy:
10.1021/jf101388z

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Journal:
Journal of agricultural and food chemistry
Volume:
58
Issue:
14
Pages:
8414-8417
Publication date:
2010-07-05
DOI:
EISSN:
1520-5118
ISSN:
0021-8561
URN:
uuid:d00a036e-4dd1-4016-999f-1674e6fa1d85
Source identifiers:
244224
Local pid:
pubs:244224

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