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TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.

Abstract:

BACKGROUND: Mutations in the cardiac Na(+) channel gene (SCN5A) can adversely affect electric function in the heart, but effects can be age dependent. We explored the interacting effects of Scn5a disruption and aging on the pathogenesis of sinus node dysfunction in a heterozygous Scn5a knockout (Scn5a(+/-)) mouse model. METHODS AND RESULTS: We compared functional, histological, and molecular features in young (3 to 4 month) and old (1 year) wild type and Scn5a(+/-) mice. Both Scn5a disruption...

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Publication status:
Published

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Publisher copy:
10.1161/circep.110.960807

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Journal:
Circulation. Arrhythmia and electrophysiology
Volume:
4
Issue:
3
Pages:
397-406
Publication date:
2011-06-01
DOI:
EISSN:
1941-3084
ISSN:
1941-3149
Source identifiers:
418446

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