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DOCK8 is essential for T-cell survival and the maintenance of CD8 + T-cell memory

Abstract:

Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8) causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and viral infections. We have recently identified a DOCK8-deficient mouse strain, carrying an ethylnitrosourea-induced splice-site mutation that shows a failure to mature a humoral immune response due to the loss of germinal centre B cells. In this study, we turned to T-cell immunity to investigate further the human immunodefi...

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Publisher copy:
10.1002/eji.201141759

Authors


Crawford, G More by this author
Johnson, AL More by this author
Crockford, TL More by this author
Bouriez-Jones, T More by this author
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Journal:
European Journal of Immunology
Volume:
41
Issue:
12
Pages:
3423-3435
Publication date:
2011-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:d005365a-96cd-4864-b7f7-528a6f8da94b
Source identifiers:
216538
Local pid:
pubs:216538
Language:
English
Keywords:

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