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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Abstract:

Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 forms a complex with apoptosis-associated speck-like protein containing a CARD domain (ASC) followed by formation of the active inflammasome. Identification of inhibitors of NLRP3 activation requires a well-validated primary high-throughput assay followed ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-021-94850-w

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Institution:
University of Oxford
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
11
Issue:
1
Article number:
15319
Publication date:
2021-07-28
Acceptance date:
2021-07-13
DOI:
EISSN:
2045-2322
Pmid:
34321581
Language:
English
Keywords:
Pubs id:
1189589
Local pid:
pubs:1189589
Deposit date:
2023-01-10

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