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Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.

Abstract:

RATIONALE: Tuberculosis remains a major cause of morbidity and mortality in the developing world. A better understanding of the mechanisms of disease protection could allow novel strategies to disease management and control. OBJECTIVES: To identify human genomic loci with evidence of linkage to tuberculosis susceptibility and, within these loci, to identify individual genes influencing tuberculosis susceptibility. METHODS: Affected sibling pair analysis in South African and Malawian populati...

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Publication status:
Published

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Publisher copy:
10.1164/rccm.200710-1554oc

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
American journal of respiratory and critical care medicine
Volume:
178
Issue:
2
Pages:
203-207
Publication date:
2008-07-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:cffeb10a-3fb2-4c93-bdfc-a21044294531
Source identifiers:
34204
Local pid:
pubs:34204

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