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Compaction of single DNA molecules induced by binding of integration host factor (IHF).

Abstract:

We studied the interaction between the integration host factor (IHF), a major nucleoid-associated protein in bacteria, and single DNA molecules. Force-extension measurements of lambda DNA and an analysis of the Brownian motion of small beads tethered to a surface by single short DNA molecules, in equilibrium with an IHF solution, indicate that: (i) the DNA-IHF complex retains a random, although more compact, coiled configuration for zero or small values of the tension, (ii) IHF induces DNA co...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.181029198

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
98
Issue:
19
Pages:
10658-10663
Publication date:
2001-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:cffceb81-fad2-432e-a39c-2674c5ab6b11
Source identifiers:
31939
Local pid:
pubs:31939

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