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Thesis

Induced regulatory T cells in transplantation tolerance

Abstract:

Induced regulatory T cells (iTreg) play an important role in the induction of tolerance to self and non-self antigens. Harnessing their suppressive potential has therapeutic implications for the treatment of autoimmune conditions and transplant rejection. Although the role of TGFβ-conditioned iTreg in natural and therapeutic tolerance is indisputable, their mechanism of action as well as factors that influence their function and stability in vivo remain unclear. Here it is shown t...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Therapeutic Immunology Group
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
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Grant:
Funding agency for:
Chen, Y
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:cffc275b-d32c-495e-a1da-55421a57e7e7
Local pid:
ora:12095

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