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Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4.

Abstract:

T cell adhesion induced after physiological stimulation by antigen was investigated using murine T cell hybridomas specific for a tetanus toxin peptide. By employing a novel assay, the T cell hybridomas were shown to strongly adhere to peptide-pulsed APC in a dose-dependent fashion. Adhesion peaked at 30-60 min and declined thereafter. This assay allowed us to study the relationship between T cell adhesion and later activation responses using tetanus toxin peptide and alanine monosubstituted ...

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Publication status:
Published

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Publisher copy:
10.1006/cimm.1996.0264

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Cellular immunology
Volume:
173
Issue:
2
Pages:
165-175
Publication date:
1996-11-05
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
URN:
uuid:cff17dcb-6146-4dfe-a77f-5a05677ce553
Source identifiers:
27595
Local pid:
pubs:27595

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