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TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells.

Abstract:

Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is associated with reduced Foxp3 expression, function, and loss of phenotypic stability. Previous studies have established the importance of TNF receptor 2 (TNFR2) in the generation and/or activation of Treg cells. In this study, we assess the importance of TNFR2 in healthy mice and under inflammatory conditions. Our findings reveal that, in health...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1909687116

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Institution:
University of Oxford
Department:
NDORMS
Role:
Author
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
116
Issue:
43
Pages:
21666-21672
Publication date:
2019-10-09
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
31597740
Language:
English
Keywords:
Pubs id:
pubs:1063542
UUID:
uuid:cfefd40c-1458-4c06-83ac-53f0a2af843a
Local pid:
pubs:1063542
Source identifiers:
1063542
Deposit date:
2019-11-01

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