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The zwitterionic type I Streptococcus pneumoniae polysaccharide does not induce memory B cell formation in humans.

Abstract:

In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to Sp1-induced T cell proliferation, a hallmark of thymus-dependent immune responses. We used peripheral blood mononuclear cells obtained from adults enrolled in a randomised clinica...

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Publication status:
Published

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Publisher copy:
10.1016/j.imbio.2012.05.008

Authors


Lazarus, R More by this author
Clutterbuck, EA More by this author
Kibwana, E More by this author
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Journal:
Immunobiology
Volume:
218
Issue:
3
Pages:
368-372
Publication date:
2013-03-05
DOI:
EISSN:
1878-3279
ISSN:
0171-2985
URN:
uuid:cfe3d163-c82d-4077-a8af-bc6a6dbf1016
Source identifiers:
339884
Local pid:
pubs:339884

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