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Gold-catalyzed cascade cyclization-oxidative alkynylation of allenoates.

Abstract:
A gold(I)-catalyzed cascade cyclization-oxidative cross-coupling process has been applied to prepare β-alkynyl-γ-butenolides directly from allenoates and various terminal alkynes. Following an initial gold-catalyzed C-O bond forming allenoate cyclization, a mechanism based on a Au(I)/Au(III) redox cycle has been proposed with Selectfluor acting as the external oxidant.
Publication status:
Published

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Publisher copy:
10.1021/ol102061k

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Organic letters
Volume:
12
Issue:
21
Pages:
4904-4907
Publication date:
2010-11-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:cfe1a556-7170-41e7-a4d6-ffdbddc03e78
Source identifiers:
90292
Local pid:
pubs:90292

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