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Journal article

Synonymous codon usage influences the local protein structure observed.

Abstract:

Translation of mRNA into protein is a unidirectional information flow process. Analysing the input (mRNA) and output (protein) of translation, we find that local protein structure information is encoded in the mRNA nucleotide sequence. The Coding Sequence and Structure (CSandS) database developed in this work provides a detailed mapping between over 4000 solved protein structures and their mRNA. CSandS facilitates a comprehensive analysis of codon usage over many organisms. In assigning trans...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkq495

Authors


Journal:
Nucleic acids research
Volume:
38
Issue:
19
Pages:
6719-6728
Publication date:
2010-10-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:cfd8f42b-78d8-4c68-a630-d9845f8a5f5a
Source identifiers:
97660
Local pid:
pubs:97660

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