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Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice.

Abstract:

The strong association of HLA B27 with spondyloarthropathies contrasts strikingly with most autoimmune diseases, which are HLA class II associated and thought to be mediated by CD4+ T lymphocytes. By introducing a human-derived HLA B27-restricted TCR into HLA B27 transgenic mice, we have obtained a functional TCR transgenic model, GRb, dependent on HLA B27 for response. Surprisingly, HLA B27 supported CD4+ as well as CD8+ T cell responses in vivo and in vitro. Further, HLA B27-restricted CD4+...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.172.1.155

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Journal of Immunology
Volume:
172
Issue:
1
Pages:
155-161
Publication date:
2004-01-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
32582

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