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Drug therapies for attentional disorders alter the signal-to-noise ratio in the superior colliculus.

Abstract:

Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but also strongly implicated in distractibility, a core symptom of ADHD. We used male juvenile Wistar rats to examine the effects of therapeutically relevant doses of methylphenidate ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuroscience
Volume:
164
Issue:
3
Pages:
1369-1376
Publication date:
2009-12-05
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:cfcff9e7-83f5-4bb8-88a9-0a27010db3f8
Source identifiers:
185111
Local pid:
pubs:185111

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