Journal article icon

Journal article

Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.

Abstract:

Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline mutations in the nuclear gene encoding fumarate hydratase (FH), an enzyme catalyzing the hydration of fumarate in the Krebs tricarboxylic acid cycle, cause hereditary leiomyomatosis and renal cell cancer; yet the connection between disruption of mitochondrial metabolic pathways and neoplasia remains to be discovered. We have used an expression microarray approach for stu...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/ddi431

Authors


Vanharanta, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Lehtonen, HJ More by this author
Sjöberg, J More by this author
Expand authors...
Journal:
Human molecular genetics
Volume:
15
Issue:
1
Pages:
97-103
Publication date:
2006-01-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:cfce9d55-52d6-496f-878b-a1674bb978b1
Source identifiers:
72246
Local pid:
pubs:72246

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP