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Thesis

Hypoxia-activated small molecule-induced gene expression

Abstract:

Hypoxia, conditions of insufficient oxygen, can occur in a wide variety of biological environments, including solid tumours, bacterial biofilms, and plants. Hypoxic tumours are associated with aggressive tumour phenotypes, increased resistance to radio- and chemotherapy, and poor patient prognosis. In biofilms, low oxygen delivery to cells causes significant reduction in bacterial growth rates, which increases resistance to antibiotics. Plants most commonly become hypoxic through flooding,...

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Department:
Department of Chemistry

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Department:
Department of Chemistry
Role:
Supervisor
Department:
Department of Oncology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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