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Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA.

Abstract:

Multi-subunit RNA polymerases (RNAPs) in all three domains of life share a common ancestry. The composition of the archaeal RNAP (aRNAP) is not identical between phyla and species, with subunits Rpo8 and Rpo13 found in restricted subsets of archaea. While Rpo8 has an ortholog, Rpb8, in the nuclear eukaryal RNAPs, Rpo13 lacks clear eukaryal orthologs. Here, we report crystal structures of the DNA-bound and free form of the aRNAP from Sulfolobus shibatae. Together with biochemical and biophysic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gks692

Authors


Wojtas, MN More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Abrescia, NG More by this author
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Funding agency for:
Bell, SD
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
19
Pages:
9941-9952
Publication date:
2012-10-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:cfc58ff5-bb60-4359-8a4c-540276f3de9a
Source identifiers:
344124
Local pid:
pubs:344124

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