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Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.

Abstract:

Superoxide anion plays important roles in vascular disease states. Increased superoxide production contributes to reduced nitric oxide (NO) bioactivity and endothelial dysfunction in experimental models of vascular disease. We measured superoxide production by NAD(P)H oxidase in human blood vessels and examined the relationships between NAD(P)H oxidase activity, NO-mediated endothelial function, and clinical risk factors for atherosclerosis. Endothelium-dependent vasorelaxations and direct me...

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Publication status:
Published

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Publisher copy:
10.1161/01.res.86.9.e85

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Journal:
Circulation research More from this journal
Volume:
86
Issue:
9
Pages:
E85-E90
Publication date:
2000-05-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:105232
UUID:
uuid:cfc314f6-6149-481c-8d69-2bca9a7934e8
Local pid:
pubs:105232
Source identifiers:
105232
Deposit date:
2012-12-19

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