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A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

Abstract:

MOTIVATION: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies. RESULTS: We present a novel pseudo Bayes factor (PBF) approach that assess differences in covariance of genotype frequencies from single nucleotide polymorphism (SNP) data from a genome-wide study. The magnitude of the PBF reflects the strength of evidence for a differe...

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Publication status:
Published

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Authors


Campino, SG More by this author
Anastasi, E More by this author
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Journal:
Bioinformatics (Oxford, England)
Volume:
26
Issue:
16
Pages:
1999-2003
Publication date:
2010-08-05
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
URN:
uuid:cfc0d04d-c320-4df5-b5bf-790caaa13e71
Source identifiers:
66069
Local pid:
pubs:66069

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