Journal article
Aberrant methylation underlies insulin gene expression in human insulinoma
- Abstract:
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Human insulinomas are rare, benign, slowly proliferating, insulin-producing beta cell tumors that provide a molecular “recipe” or “roadmap” for pathways that control human beta cell regeneration. An earlier study revealed abnormal methylation in the imprinted p15.5-p15.4 region of chromosome 11, known to be abnormally methylated in another disorder of expanded beta cell mass and function: the focal variant of congenital hyperinsulinism. Here, we compare deep DNA methylome sequencing on 19 hum...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 3.3MB)
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- Publisher copy:
- 10.1038/s41467-020-18839-1
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Article number:
- 5210
- Publication date:
- 2020-10-15
- Acceptance date:
- 2020-09-16
- DOI:
- EISSN:
-
2041-1723
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Pubs id:
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1137278
- Local pid:
- pubs:1137278
- Deposit date:
- 2020-10-12
Terms of use
- Copyright holder:
- Karakose, E et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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