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Aberrant methylation underlies insulin gene expression in human insulinoma

Abstract:

Human insulinomas are rare, benign, slowly proliferating, insulin-producing beta cell tumors that provide a molecular “recipe” or “roadmap” for pathways that control human beta cell regeneration. An earlier study revealed abnormal methylation in the imprinted p15.5-p15.4 region of chromosome 11, known to be abnormally methylated in another disorder of expanded beta cell mass and function: the focal variant of congenital hyperinsulinism. Here, we compare deep DNA methylome sequencing on 19 hum...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Subgroup:
OCDEM
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
5210
Publication date:
2020-10-15
Acceptance date:
2020-09-16
DOI:
EISSN:
2041-1723
Pubs id:
1137278
Local pid:
pubs:1137278

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