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Evidence for increased in vivo Na(+)-H+ antiporter activity and an altered skeletal muscle contractile response in the spontaneously hypertensive rat.

Abstract:

We have assessed the in vivo activity of the Na(+)-H+ antiporter skeletal muscle in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls using phosphorus (31P) nuclear magnetic resonance spectroscopy to measure changes in cytosolic acid concentrations during isometric contraction. During contraction there was a small rate of rise in skeletal muscle cytosolic acid concentration to a smaller maximum concentration in SHR. This difference in acid response was removed by amiloride...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Role:
Author
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Journal:
Journal of hypertension
Volume:
8
Issue:
11
Pages:
1027-1036
Publication date:
1990-11-05
DOI:
EISSN:
1473-5598
ISSN:
0263-6352
URN:
uuid:cfc00466-35d2-4477-98e6-c8e7b39753b6
Source identifiers:
322054
Local pid:
pubs:322054

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