- Abstract:
-
We have assessed the in vivo activity of the Na(+)-H+ antiporter skeletal muscle in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls using phosphorus (31P) nuclear magnetic resonance spectroscopy to measure changes in cytosolic acid concentrations during isometric contraction. During contraction there was a small rate of rise in skeletal muscle cytosolic acid concentration to a smaller maximum concentration in SHR. This difference in acid response was removed by amiloride...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/00004872-199011000-00009
-
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- Journal:
- Journal of hypertension
- Volume:
- 8
- Issue:
- 11
- Pages:
- 1027-1036
- Publication date:
- 1990-11-05
- DOI:
- EISSN:
-
1473-5598
- ISSN:
-
0263-6352
- URN:
-
uuid:cfc00466-35d2-4477-98e6-c8e7b39753b6
- Source identifiers:
-
322054
- Local pid:
- pubs:322054
- Copyright date:
- 1990
Journal article
Evidence for increased in vivo Na(+)-H+ antiporter activity and an altered skeletal muscle contractile response in the spontaneously hypertensive rat.
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