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Thesis

Functional analysis of polymorphisms associated with osteoarthritis susceptibility that affect cis-regulation

Abstract:

Osteoarthritis (OA) is a common, multifactorial disease that is characterized by focal degeneration of the smooth articular cartilage in any of the synovial joints. Although the underlying molecular mechanisms for OA are still not fully understood, epidemiological studies have evidenced a significant genetic component to OA susceptibility. Genome-wide linkage scans and large-scale association studies have had success in unraveling the genetic architecture underlying OA with the identification...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Oriel College
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Wilkins, J
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:cfbed303-bdfd-4bb4-bd8f-a3dcd63167bc
Local pid:
ora:8419
Deposit date:
2014-05-12

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