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Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data.

Abstract:

BACKGROUND: TRACK-HD is a prospective observational biomarker study in premanifest and early Huntington's disease (HD). In this report we define a battery of potential outcome measures for therapeutic trials. METHODS: We assessed longitudinal data collected at baseline, 12 months, and 24 months at sites in Leiden (Netherlands), London (UK), Paris (France), and Vancouver (Canada). Participants were individuals without HD but carrying the mutant HTT gene (ie, premanifest HD), patients with earl...

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Publication status:
Published

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Journal:
Lancet. Neurology
Volume:
11
Issue:
1
Pages:
42-53
Publication date:
2012-01-01
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
Source identifiers:
222456

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