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Antigenicity and Immunogenicity in HIV-1 Antibody-Based Vaccine Design.

Abstract:

Neutralizing antibodies can protect from infection by immunodeficiency viruses. However, the induction by active vaccination of antibodies that can potently neutralize a broad range of circulating virus strains is a goal not yet achieved, despite more than 2 decades of research. Here we review progress made in the field, from early empirical studies to today's rational structure-based vaccine antigen design. We discuss the existence of broadly neutralizing antibodies, their implications for e...

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Publisher copy:
10.4172/2155-6113

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of AIDS and clinical research
Volume:
S8
Pages:
3
Publication date:
2012-01-01
DOI:
EISSN:
2155-6113
ISSN:
2155-6113
URN:
uuid:cfbe4b09-217b-4a05-89ac-68414f3e0320
Source identifiers:
367639
Local pid:
pubs:367639
Language:
English

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