Journal article icon

Journal article

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.

Abstract:

Epithelial to mesenchymal transition (EMT), and the reverse mesenchymal to epithelial transition (MET), are known examples of epithelial plasticity that are important in kidney development and cancer metastasis. Here we identify ASPP2, a haploinsufficient tumour suppressor, p53 activator and PAR3 binding partner, as a molecular switch of MET and EMT. ASPP2 contributes to MET in mouse kidney in vivo. Mechanistically, ASPP2 induces MET through its PAR3-binding amino-terminus, independently of p...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ncb3050

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Nature Publishing Group
Journal:
Nature cell biology More from this journal
Volume:
16
Issue:
11
Pages:
1092-1104
Publication date:
2014-11-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Language:
English
Pubs id:
pubs:488274
UUID:
uuid:cfbd4f76-e0aa-4ba5-9979-bd4f9656f540
Local pid:
pubs:488274
Source identifiers:
488274
Deposit date:
2014-11-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP