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Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro.

Abstract:

In humans, many responses to hypoxia including angiogenesis and erythropoiesis are mediated by the alpha/beta-heterodimeric transcription factor hypoxia inducible factor (HIF). The stability and/or activity of human HIF-1alpha are modulated by post-translational modifications including prolyl and asparaginyl hydroxylation, phosphorylation, and reportedly by acetylation of the side-chain of Lys532 by ARD1 (arrest defective protein 1 homologue), an acetyltransferase. Using purified recombinant ...

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Publication status:
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Authors


Murray-Rust, TA More by this author
Oldham, NJ More by this author
Hewitson, KS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
FEBS letters
Volume:
580
Issue:
8
Pages:
1911-1918
Publication date:
2006-04-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:cfbcdf5e-6eb1-4f56-9f50-fb03503a3110
Source identifiers:
33406
Local pid:
pubs:33406

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