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Haplotype matching in large cohorts using the Li and Stephens model

Abstract:
Motivation The Li and Stephens model, which approximates the coalescent describing the pattern of variation in a population, underpins a range of key tools and results in genetics. Although highly efficient compared to the coalescent, standard implementations of this model still cannot deal with the very large reference cohorts that are starting to become available, and practical implementations use heuristics to achieve reasonable runtimes. Results Here I d... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/bioinformatics/bty735

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Oxford college:
St Hughs College
ORCID:
0000-0002-3798-2058
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
35
Issue:
5
Pages:
798–806
Publication date:
2018-08-25
Acceptance date:
2018-08-23
DOI:
EISSN:
1460-2059
ISSN:
1367-4803
Pubs id:
pubs:919066
URN:
uri:cfbc4f57-6760-4e36-8f11-639168362fa1
UUID:
uuid:cfbc4f57-6760-4e36-8f11-639168362fa1
Local pid:
pubs:919066
Language:
English
Keywords:

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