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Haplotype matching in large cohorts using the Li and Stephens model

Abstract:
Motivation The Li and Stephens model, which approximates the coalescent describing the pattern of variation in a population, underpins a range of key tools and results in genetics. Although highly efficient compared to the coalescent, standard implementations of this model still cannot deal with the very large reference cohorts that are starting to become available, and practical implementations use heuristics to achieve reasonable runtimes. Results Here I d... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/bioinformatics/bty735

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-3798-2058
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
35
Issue:
5
Pages:
798–806
Publication date:
2018-08-25
Acceptance date:
2018-08-23
DOI:
EISSN:
1460-2059
ISSN:
1367-4803
Pmid:
30165547
Language:
English
Keywords:
Pubs id:
pubs:919066
UUID:
uuid:cfbc4f57-6760-4e36-8f11-639168362fa1
Local pid:
pubs:919066
Deposit date:
2018-09-17

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