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Potent anti‐inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells

Abstract:

Background and Purpose To investigate whether a narrow spectrum kinase inhibitor RV1088, which simultaneously targets specific MAPKs, Src and spleen tyrosine kinase (Syk), is more effective at inhibiting inflammatory signalling in rheumatoid arthritis (RA) than single kinase inhibitors (SKIs). Experimental Approach elisas were used to determine the efficacy of RV1088, clinically relevant SKIs and the pharmaceutical Humira on pro‐inflammatory cytokine production by activated RA synovial fibrob...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/bph.13170

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-8813-2977
More from this funder
Name:
Versus Arthritis
Grant:
20003
More from this funder
Name:
Arthritis Research UK
Grant:
20003
Publisher:
Wiley
Journal:
British Journal of Pharmacology More from this journal
Volume:
172
Issue:
15
Pages:
3805-3816
Publication date:
2015-04-17
Acceptance date:
2015-04-08
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Pmid:
25891413
Language:
English
Keywords:
Pubs id:
pubs:521542
UUID:
uuid:cfba71a8-2df5-45c6-9227-4780cc171ae4
Local pid:
pubs:521542
Source identifiers:
521542
Deposit date:
2019-05-22

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