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Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.

Abstract:

The human enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) catalyzes the reversible oxidoreduction of 11beta-OH/11-oxo groups of glucocorticoid hormones. Besides this important endocrinological property, the type 1 isozyme (11beta-HSD1) mediates reductive phase I reactions of several carbonyl group bearing xenobiotics, including drugs, insecticides and carcinogens. The aim of this study was to explore novel substrate specificities of human 11beta-HSD1, using heterologously expressed pr...

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Journal:
Chemico-biological interactions
Volume:
130-132
Issue:
1-3
Pages:
805-814
Publication date:
2001-01-01
DOI:
EISSN:
1872-7786
ISSN:
0009-2797
Source identifiers:
108611

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