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Thioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. Results from MRC CML. II. Trial comparing busulphan with busulphan and thioguanine.

Abstract:

Portal hypertension with varices developed in 18/675 patients with chronic myeloid leukaemia (CML) in a randomized trial comparing busulphan with busulphan and thioguanine. All 18 had received the drug combination and none busulphan alone (P less than 0.0001). Ascites was also seen significantly more often in the combination arm (P less than 0.05). These results strongly suggest that the addition of thioguanine was responsible for the development of portal hypertension. The histological featu...

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Publication status:
Published

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Authors


Shepherd, PC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
British journal of haematology
Volume:
79
Issue:
2
Pages:
185-192
Publication date:
1991-10-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:cfab1dab-d98b-4274-b548-a184ee117110
Source identifiers:
326933
Local pid:
pubs:326933

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