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Journal article

Regulation of mRNA levels by decay-promoting introns that recruit the exosome specificity factor Mmi1

Abstract:

In eukaryotic cells, inefficient splicing is surprisingly common and leads to degradation of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is unknown. Here we uncover a mechanism by which specific intron-containing transcripts are targeted for nuclear degradation in fission yeast. Sequence elements within these “decay-promoting” introns co-transcriptionally recruit the exosome specificity factor Mmi1, which induces degradation of the unspliced precursor and l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2015.11.026

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Medical Research Council More from this funder
Exeter College, Oxford More from this funder
Hilla Ginwala Scholarship More from this funder
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Grant:
WT091549
WT088359MA
WT106994MA
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
13
Issue:
11
Pages:
2504-2515
Publication date:
2015-01-01
DOI:
ISSN:
2211-1247
Source identifiers:
577322
Language:
English
Keywords:
Pubs id:
pubs:577322
UUID:
uuid:cfa83518-09c3-4cc8-9e06-2653ec7609a1
Local pid:
pubs:577322
Deposit date:
2015-12-01

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